|
KMID : 0382619840040020595
|
|
Hanyang Journal of Medicine
1984 Volume.4 No. 2 p.595 ~ p.610
|
|
|
Depressor Responses to Intravenously Administered Porcine Bile in the Cat
|
|
|
|
|
Abstract
|
|
|
The present study was carried out in order to investigate the effects of intravenously ad-ministered porcine bile on blood pressure in cats. Depressor activity of Sigma porcine bile (obtained from Sigma chemical company) was compared with that of dried porcine bile (prepared in our laboratory). Also studied was effects of atropine, propranolol and regitine pretreatment on the depressor responses ell sited by intravenously administered porcine bile.
The results obtained are as follows;
1. Following intravenous administration of Sigma porcine bile, depressor responses were elicited invariably. After administration of 20mg/Kg and 30mg/Kg Sigma porcine bile the mean maximum depressor responses observed were 46.4 4.2mmHg and 75.5 6.1rmnHg, respectively.
2. The maximum depressor responses to 20mg / Kg and 30mg / Kg of intravenously ad-ministered dried porcine bile were respectively 37.5 3.8mmHg and 55.6 4.2mmHg, showing that. depressor activity of Sigma porcine bile was far greater than that of the dried one.
3. No changes in depressor responses to Sigma bile were observed in the animals pretreated either with atropine or propranolol. However, partial blockade of depressor activity of porcine bile was recognized in animals pretreated with regitine.
4. After intravenous administration of Sigma bile solution (30mg / Kg) a short period of apnea was generally followed by polypnea.
It is indicated from results of the present study that depressor responses to intravenously ad-ministered porcine bile is partly due to blockade of adrenergic d-receptor and mostly due to direct action of bile on vascular smooth muscle.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|